Nucleoside conjugates. 11. Synthesis and antitumor activity of 1-. beta.-D-arabinofuranosylcytosine and cytidine conjugates of thioether lipids

…, AJ Kirisits, A Nechaev, DJ Buchheit…

Index: Il Hong; Kirisits; Nechaev; Buchheit; West Journal of Medicinal Chemistry, 1990 , vol. 33, # 5 p. 1380 - 1386

Full Text: HTML

Citation Number: 34

Abstract

Five lPD-arabinofuranosylcytosine conjugates and two cytidine conjugates of thioether lipids (1-S-alkylthioglycerolsj linked by a pyrophosphate diester bond have been prepared and their antitumor activity against an ara-C2 sensitive (L1210/0) and two ara-C resistant L1210 lymphoid leukemia sublines in mice were evaluated. These prodrugs of ara-C include ara- CDP-rac-lS-hexadecyl-2-0-palmitoyl-l-thioglycerol@ a), ara-CDP-rac-lS-octadecyl-2-0- ...