Synthesis of a new photolabile support. 4-(2-Chloropropionyl) phenylacetamidomethyl-resin and its application in solid-phase peptide synthesis

FS Tjoeng, GA Heavner

Index: Tjoeng, Foe-Siong; Heavner, George A. Journal of Organic Chemistry, 1983 , vol. 48, # 3 p. 355 - 359

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Citation Number: 34

Abstract

The preparation of a new photolabile resin for solid-phase peptide synthesis is described.[4- (2-Chloropropionyl) phenyl] acetic acid was used as the handle and was obtained in three steps with an 82% overall yield on starting from phenylacetic acid. The incorporation of the handle to the aminomethyl-resin to form 4-(2-chloropropiony1) phenylacetamidomethyLresin was achieved via its acid chloride or ...