Synthesis and antiplasmodial activity of new heteroaryl derivatives of 7-chloro-4-aminoquinoline

…, A Barteselli, N Basilico, S Parapini, D Taramelli…

Index: Casagrande, Manolo; Barteselli, Anna; Basilico, Nicoletta; Parapini, Silvia; Taramelli, Donatella; Sparatore, Anna Bioorganic and Medicinal Chemistry, 2012 , vol. 20, # 19 p. 5965 - 5979

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Citation Number: 14

Abstract

With the aim to investigate the effect of different heterocyclic rings linked to the 4- aminoquinoline nucleus on the antimalarial activity, a set of 7-chloro-N-(heteroaryl)-methyl-4- aminoquinoline and 7-chloro-N-(heteroaryl)-4-aminoquinoline was synthesized and tested in vitro against D-10 (CQ-S) and W-2 (CQ-R) strains of Plasmodium falciparum. All compounds exhibited from moderate to high antiplasmodial activities. The activity was ...