Chemistry Letters

Reductive Ti-crossed Claisen Condensation between Methyl. ALPHA.-Bromocarboxylates and Acid Chlorides Utilizing a TiCl4-PPh3-N-Methylimidazole Reagent

A Iida, S Nakazawa, H Nakatsuji, T Misaki, Y Tanabe

Index: Iida, Akira; Nakazawa, Syogo; Nakatsuji, Hidefumi; Misaki, Tomonori; Tanabe, Yoo Chemistry Letters, 2007 , vol. 36, # 1 p. 48 - 49

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Citation Number: 4

Abstract

Reductive Ti-crossed Claisen condensation between methyl α-bromocarboxylates and acid chlorides utilizing a TiCl 4–PPh 3–N-methylimidazole reagent proceeded smoothly to give the α-monosubstituted and thermodynamically unfavorable α, α-disubstituted β-keto methyl esters in good to excellent yields (33 examples; 73–96% yield).

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