N-heterocyclic carbenes mediated cyano-phosphorylation of ketones

L He, J Zhang, YC Fan, GF Du, J Zhang, B Dai

Index: He, Lin; Zhang, Jing; Fan, Ye-Cheng; Du, Guang-Fen; Zhang, Jie; Dai, Bin Tetrahedron Letters, 2013 , vol. 54, # 44 p. 5861 - 5864

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Citation Number: 2

Abstract

Abstract Cyanation-O-protection reaction of ketones with different cyanide sources catalyzed by N-heterocyclic carbenes is reported. Under the catalysis of 1, 3-bis (2, 6- diisopropylphenyl) imidazol-2-ylidene, various ketones coupled with diethyl cyanophosphonate to produce cyanohydrin-O-phosphates with a quaternary carbon center in moderate to excellent yield. Furthermore, the reaction can be scaled-up easily and high ...