1-(2-Aminoethyl)-3-(arylsulfonyl)-1H-pyrrolopyridines are 5-HT 6 receptor ligands

…, GM Zhang, D Smith, J Coupet, LE Schechter

Index: Bernotas, Ronald C.; Antane, Schuyler A.; Lenicek, Steven E.; Haydar, Simon N.; Robichaud, Albert J.; Harrison, Boyd L.; Zhang, Guo Ming; Smith, Deborah; Coupet, Joseph; Schechter, Lee E. Bioorganic and Medicinal Chemistry Letters, 2009 , vol. 19, # 24 p. 6935 - 6938

Full Text: HTML

Citation Number: 8

Abstract

Download PDF Opens in a new window. Article suggestions will be shown in a dialog on return to ScienceDirect. ... Please enable JavaScript to use all the features on this page. ... 1-(2-Aminoethyl)-3-(arylsulfonyl)-1H-pyrrolopyridines were prepared. Binding assays indicated they are 5-HT 6 receptor ligands, among which 6f and 6g showed high affinity for 5-HT 6 receptors with K i = 3.9 and 1.7 nM, respectively. ... Pyrrolopyridines 4, 5, and 6 have been ...