Synthesis and bronchodilator activity of new quinazolin derivative

…, A Bhagat, OP Gupta, GD Singh, MS Youssouf…

Index: Zabeer; Bhagat; Gupta; Singh; Youssouf; Dhar; Suri; Satti; Qazi European Journal of Medicinal Chemistry, 2006 , vol. 41, # 3 p. 429 - 434

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Citation Number: 35

Abstract

Taking lead from a naturally occurring quinazolin vasicine, a number of compounds were developed and evaluated for bronchodilator and anti-allergic activities. One of these compounds was 2, 4-diethoxy-6, 7, 8, 9, 10, 12-hexahydroazepino [2, 1-b] quinazolin-12- one, hereinafter named 95-4, exhibited marked bronchodilator activity evaluated on contracted trachea or constricted tracheo-bronchial tree. On intestinal smooth muscle too it ...

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