Chemistry Letters

New method for the synthesis of podoblastin derivatives and 3-acyltetronic acids

H Kawakami, S Hirokawa, M Asaoka, H Takei

Index: Kawakami, Hiroshi; Hirokawa, Shinya; Asaoka, Morio; Takei, Hisashi Chemistry Letters, 1987 , p. 85 - 88

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Citation Number: 6

Abstract

A new and general method for the synthesis of podoblastin derivatives and 3-acyltetronic acids via isoxazoles is described. The key isoxazole intermediates were obtained by 1, 3- dipolar cycloaddition reaction of acetylenecarboxylic acid derivatives to nitrile oxides. These isoxazoles were readily converted to the title compounds by hydrogenolysis followed by hydrolysis and cyclization.