Identification of novel scaffold of benzothiazepinones as non-ATP competitive glycogen synthase kinase-3β inhibitors through virtual screening

P Zhang, HR Hu, ZH Huang, JY Lei, Y Chu…

Index: Zhang, Peng; Hu, Hai-Rong; Huang, Zhao-Hui; Lei, Jia-Yi; Chu, Yong; Ye, De-Yong Bioorganic and Medicinal Chemistry Letters, 2012 , vol. 22, # 23 p. 7232 - 7236

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Citation Number: 9

Abstract

Glycogen synthase kinase-3β (GSK-3β) is an important serine/threonine kinase that has been proved as a key target for neurodegenerative diseases and diabetes. Up to date, most of known inhibitors are bound to the ATP-binding pocket of GSK-3β, which might lead widespread effects due to the high homology between kinases. Recently, some of its non- ATP competitive inhibitors had been confirmed having therapeutical effects owing to their ...