Medicinal Chemistry Research

Synthesis and analgesic activity of new pyridine-based heterocyclic derivatives

G Nigade, P Chavan, M Deodhar

Index: Nigade, Ganesh; Chavan, Pradeep; Deodhar, Meenakshi Medicinal Chemistry Research, 2012 , vol. 21, # 1 p. 27 - 37

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Citation Number: 5

Abstract

Abstract A series of new heterocyclic derivatives having a pyridine nucleus were synthesized. 4-(5-(2-Chlorophenyl)-4H-1, 2, 4-triazol-3-yl) pyridine (7c) and 4-(5-(2- Nitrophenyl)-4H-1, 2, 4-triazol-3-yl) pyridine (7d) presented the best analgesic profie of this series in hot-plate, tail-flick, and formalin-induced licking tests, which was partially prevented by pretreatment with mecamylamine, a nicotinic receptor antagonist.