An improved synthesis of optically active steroids
T ASAKO, K HIRAGA, T MIKI
Index: Asako,T. et al. Chemical and Pharmaceutical Bulletin, 1973 , vol. 21, # 1 p. 107 - 111
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Citation Number: 8
Abstract
17α-Hydroxy-3-methoxy-8, 14-secoestra-1, 3, 5 (10), 9-tetraen-14-one (IIa) which is an intermediate for the total synthesis of estrogens has been optically resolved. The isomer which has unnatural configuration at C-13 has been converted to estrapentaene 3-methyl ether (IVa) via the 9, 14-epoxy intermediates (XI, XII, XIII, XV).
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