Synlett

Highly regioselective synthesis of 1-aryl-3, 4, 5-substituted pyrazoles

F Gosselin, PD O'Shea, RA Webster, RA Reamer…

Index: Gosselin, Francis; O'Shea, Paul D.; Webster, Robert A.; Reamer, Robert A.; Tillyer, Richard D.; Grabowski, Edward J. J. Synlett, 2006 , # 19 p. 3267 - 3270

Full Text: HTML

Citation Number: 61

Abstract

We have found that in the cyclocondensation of arylhydrazine hydrochlorides with 1,3-diketones, aprotic solvents with strong dipole moments and dielectric constants consistently gave much improved results relative to polar, protic solvents such as ethanol and acetic acid which are typically used for this type of reaction. [7] Our initial evaluation of solvents for the condensation of aryl-1,3-diketones with phenylhydrazine hydrochloride indicated that amide solvents ...

Related Articles:

Facile, Selective, and Regiocontrolled Synthesis of Oxazolines and Oxazoles Mediated by ZnI2 and FeCl3

[Patil, Nitin T.; Singh, Vipender Chemical Communications, 2011 , vol. 47, # 39 p. 11116 - 11118]

A Novel Synthesis of fluorinated pyrazoles via Gold (I)-catalyzed tandem aminofluorination of alkynes in the presence of selectfluor

[Qian, Jianqiang; Liu, Yunkui; Zhu, Jie; Jiang, Bo; Xu, Zhenyuan Organic Letters, 2011 , vol. 13, # 16 p. 4220 - 4223]

Facile, Selective, and Regiocontrolled Synthesis of Oxazolines and Oxazoles Mediated by ZnI2 and FeCl3

[Patil, Nitin T.; Singh, Vipender Chemical Communications, 2011 , vol. 47, # 39 p. 11116 - 11118]

Facile, Selective, and Regiocontrolled Synthesis of Oxazolines and Oxazoles Mediated by ZnI2 and FeCl3

[Patil, Nitin T.; Singh, Vipender Chemical Communications, 2011 , vol. 47, # 39 p. 11116 - 11118]

Facile, Selective, and Regiocontrolled Synthesis of Oxazolines and Oxazoles Mediated by ZnI2 and FeCl3

[Patil, Nitin T.; Singh, Vipender Chemical Communications, 2011 , vol. 47, # 39 p. 11116 - 11118]

More Articles...