Synthesis and biological activity of novel quaternary ammonium derivatives of alkylglycerols as potent inhibitors of protein kinase C

…, KL Meyer, S Morris-Natschke, KS Ishaq…

Index: Marasco Jr.; Piantadosi; Meyer; Morris-Natschke; Ishaq; Small; Daniel Journal of Medicinal Chemistry, 1990 , vol. 33, # 3 p. 985 - 992

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Citation Number: 57

Abstract

Alkylglycerols such as rac-l-0-octadecyl-2-O-methylglycerophosphochwholiie (Et-l&OMe) have shown an inhibitory effect on the metastasis and growth of various cancer cell lines. Alkyl phospholipids have been shown to accumulate at the surface in several cell lines, the selectivity of which is still not clearly understood. A consequence of this action may lead to the inhibition of cell membrane related protein kinase C (PKC). The goal of this research ...

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