Synthesis of two bioactive natural products: FR252921 and pseudotrienic acid B

D Amans, V Bellosta, J Cossy

Index: Amans, Dominique; Bellosta, Veronique; Cossy, Janine Chemistry - A European Journal, 2009 , vol. 15, # 14 p. 3457 - 3473

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Citation Number: 22

Abstract

Abstract Jackpot: Two for one! Concise and highly convergent syntheses of the immunosuppressive agent FR252921 and the related antimicrobial natural product pseudotrienic acid B were achieved from one common intermediate by using optically active titanium complexes to control the configuration of the stereogenic centers, a highly stereo- and regioselective cross-metathesis to generate the triene moieties, and a Stille cross- ...