Chemistry–A European Journal

Dialkylamino??2, 4??dihydroxybenzoic Acids as Easily Synthesized Analogues of Platensimycin and Platencin with Comparable Antibacterial Properties

J Wang, HO Sintim

Index: Wang, Jingxin; Sintim, Herman O. Chemistry - A European Journal, 2011 , vol. 17, # 12 p. 3352 - 3357

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Citation Number: 14

Abstract

Bacterial resistance to most antibiotics has presented an enormous problem to solve for mankind. In the last decade, there have been increased efforts to identify new antibiotic targets or to develop novel chemical scaffolds to inhibit known drug targets in bacteria. It is just over four years since a group at Merck reported the identification of a novel class of antibiotics called platensimycin [1] or platencin,[2] which are FabF/H inhibitors and ...