Chemistry Letters

An expeditious synthesis of lasofoxifene and nafoxidine via the novel three-component coupling reaction

Y Sano, K Nakata, T Otoyama, S Umeda, I Shiina

Index: Sano, Yoshiyuki; Nakata, Kenya; Otoyama, Takafumi; Umeda, Sei; Shiina, Isamu Chemistry Letters, 2007 , vol. 36, # 1 p. 40 - 41

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Citation Number: 8

Abstract

The simple and efficient synthesis of lasofoxifene (4), a possible candidate for alleviating osteoporosis, via the novel three-component coupling reaction among 4- pivaloyloxybenzaldehyde (5), cinnamyltrimethylsilane (6), and anisole in the presence of HfCl 4 is illustrated. The successive cationic cyclization of the coupling product, olefin formation, and migration of the double-bond are performed to afford the common synthetic ...