New bidentates as full inhibitors of enkephalin-degrading enzymes: synthesis and analgesic properties

MC Fournie-Zaluski, A Coulaud…

Index: Fournie-Zaluski; Coulaud; Bouboutou; Chaillet; Devin; Waksman; Costentin; Roques Journal of Medicinal Chemistry, 1985 , vol. 28, # 9 p. 1158 - 1169

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Citation Number: 90

Abstract

Figure 1. Scheme for the synthesis of N-[2 (RS)-[(hydroxy-amino) carbonyl]-l-oxo-3- phenylpropyl] glycine (1) and its analogues. from these serious side effects. The discovery of endogenous opioid peptides in the brain2 which are associated with both a heterogeneity of binding sites* 5 and well-defined metabolic pathways might offer new approaches to the prevention or treatment of addiction following analgesic use. In vitro studies performed ...