The reaction of isothiocyanates with 2??cyanoethanoic acid hydrazide. A novel synthesis of 1, 3, 4??thiadiazoles

MRH Elmoghayar, SO Abdalla…

Index: Elmoghayar, Mohamed Rifaat Hamza; Abdalla, Sanaa Osman; Nasr, Mohamed Yousry Abdel-Samad Journal of Heterocyclic Chemistry, 1984 , vol. 21, p. 781 - 784

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Citation Number: 28

Abstract

Abstract Benzoyl and ethoxycarbonyl isothiocyanates reacted with 2-cyanoethanoic acid hydrazide 2 to afford 1-cyanoacetyl-4-substituted thiosemicarbazide (5a, b). Compound 5a afforded the pyrazolo [1, 5-a]-s-triazine derivative 6 on treatment with 5% potassium hydroxide, and cyclised to 2-benzoylamino-5-cyanomethyl-1, 3, 4-thiadiazole (8) when boiled under reflux in glacial acetic acid. Compound 8 condensed with aromatic ...