Rongalite® and base-promoted cleavage of disulfides and subsequent Michael addition to α, β-unsaturated ketones/esters: an odorless synthesis of β-sulfido …

W Guo, G Lv, J Chen, W Gao, J Ding, H Wu

Index: Guo, Wenxue; Lv, Guangshu; Chen, Jiuxi; Gao, Wenxia; Ding, Jinchang; Wu, Huayue Tetrahedron, 2010 , vol. 66, # 13 p. 2297 - 2300

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Citation Number: 22

Abstract

A highly practical method to access β-sulfido carbonyl compounds was developed, which could be conducted without any expensive reagent, special apparatus/technique, and no requirement of metal catalysts. β-Sulfido carbonyl compounds were formed at room temperature, in short time and with high chemoselectivity in good to excellent yields. A plausible mechanism for the role of Rongalite®, as a promoter for the cleavage of ...