Synthesis, evaluation of insecticidal activity, and crystal analysis of cis-nitenpyram analogs bearing 1, 4-dihydropyridine

C Sun, T Liu, L Ding, Y Chen, W Zhang

Index: Sun, Chuanwen; Liu, Tianyan; Ding, Li; Chen, Yanxia; Zhang, Wanggeng Monatshefte fur Chemie, 2013 , vol. 144, # 7 p. 1003 - 1012

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Abstract

Abstract A new series of nitenpyram analogs were designed by introducing 1, 4- dihydropyridine to fix the pharmacophore (–C= C–NO 2) into the cis-configuration, as confirmed by X-ray diffraction. Crystal structure analysis showed that there was a homoconjugation effect on these cis-nitenpyram analogs, and a huge conjugated system comprising the 1, 4-dihydropyridine scaffold and the ester group at the 3 position. ...