Tetrahedron Letters

A one-pot synthesis of substituted salicylnitriles

HF Anwar, TV Hansen

Index: Anwar, Hany F.; Hansen, Trond Vidar Tetrahedron Letters, 2008 , vol. 49, # 28 p. 4443 - 4445

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Citation Number: 15

Abstract

Phenols were converted to salicylaldehydes with paraformaldehyde, MgCl2–Et3N in THF, and subsequent treatment with aqueous ammonia gave the corresponding imines which were oxidized with IBX to the desired salicylnitriles. The sequence of reactions was conveniently carried out as a one-pot procedure under mild conditions.

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