Unanticipated acyloxymethylation of sumatriptan indole nitrogen atom and its implications in prodrug design

T Rodrigues, R Moreira, RC Guedes, J Iley…

Index: Archiv der Pharmazie, , vol. 341, # 6 p. 344 - 350

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Abstract

... KGaA, Weinheim www.archpharm.com Figure 3. Geometries of 4a and 5 using B3LYP/6-31+ G(d,p). Scheme 1. Hydrolysis of N-acyloxymethyl sumatriptan deriv- atives 4 in aqueous buffers. ... Pharm. Chem. Life Sci. 2008, 341, 344 – 350 Acyloxymethylation of Sumatriptan 347 ...

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