Potential carcinostatics. 4. Synthesis and biological properties of erythro-and threo-. beta.-fluoroaspartic acid and erythro-. beta.-fluoroasparagine

MJ Wanner, JJM Hageman, GJ Koomen…

Index: Wanner; Hageman; Koomen; Pandit Journal of Medicinal Chemistry, 1980 , vol. 23, # 1 p. 85 - 87

Full Text: HTML

Citation Number: 16

Abstract

(E)-and (Z)-Di-tert-butyl 2-amino-3-fluoro-2-butene-1, 4-dioate [(E)-and (-021 were synthesized in two ways:(a) by elimination of hydrogen fluoride from di-tert-butyl p, P- difluoroaspartate under the influence of 1, 5-diazabicyclo [4.3. 0] non-5-ene and (b) by amination with the ammonium acetate of di-tert-butyl monofluorooxaloacetate (3), obtained via condensation of tert-butyl monofluoroacetate with di-tert-butyl oxalate. Reduction of 2 ...