Regioselective synthesis of 7, 8-dihydroimidazo [5, 1-c][1, 2, 4] triazine-3, 6 (2H, 4H)-dione derivatives: A new drug-like heterocyclic scaffold

NT Tzvetkov, H Euler, CE Müller

Index: Tzvetkov, Nikolay T.; Euler, Harald; Mueller, Christa E. Beilstein Journal of Organic Chemistry, 2012 , vol. 8, p. 1584 - 1593

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Citation Number: 4

Abstract

Abstract Dihydroimidazo [5, 1-c][1, 2, 4] triazine-3, 6 (2H, 4H)-dione derivatives were prepared by successive N3-and N1-alkylation of hydantoins, followed by regioselective thionation and subsequent cyclization under mild conditions. In a final alkylation step a further substituent may be introduced. The synthetic strategy allows broad structural variation of this new drug-like heterobicyclic scaffold. In addition to extensive NMR and ...