Asian Journal of Chemistry

Synthesis of some pramoxine-based compounds as possible local anesthetic and anticholinergic agents

K Kucukoglu, M Tanol

Index: Kucukoglu, Kaan; Tanol, Mehmet Asian Journal of Chemistry, 2010 , vol. 22, # 5 p. 3404 - 3412

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Abstract

Abstract A pair of pramoxine-based compounds, K-94 and K-95, which are potential local anesthetic and anticholinergic agents, were synthesized using a previously synthesized Schiff base of 2-diethylamine chloride and potassium carbonate. Of the compounds synthesized, compound K-94 was new. Moreover, RM, a physicochemical parameter, has been calculated for both compounds in order to investigate the effect of these structural ...