Synthesis of 6-carboxy-2, 2-dimethylchromans and chromenes

VK Ahluwalia, RS Jolly, AK Tehim

Index: Ahluwalia, V. K.; Jolly, R. S.; Tehim, A. K. Tetrahedron, 1982 , vol. 38, # 24 p. 3673 - 3677

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Citation Number: 12

Abstract

The condensation of hydroxybenzoic acids and their methyl esters with isoprene in the presence of orthophosphoric acid gives corresponding 2, 2-dimethylchromans, which can be dehydrogenated with DDQ or NBS to give the corresponding 6-carboxy-2, 2- dimethylchromenes. The synthesis of β-tubaic acid, a natural compound, has also been achieved.