Linked aryl aryloxypropanolamines as a new class of lipid catabolic agents

MT Cox, SE Jaggers, G Jones

Index: Cox,M.T. et al. Journal of Medicinal Chemistry, 1978 , vol. 21, p. 182 - 188

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Citation Number: 6

Abstract

The synthesis of a series of stilbene, biaryl, tolane, diaryl ether, sulfide, sulfoxide, and sulfone oxypropanolamines as potential antiobesity agents is described. These compounds were evaluated in a mouse lipid catabolism screen, and the more active members of the series, 4, 57, and 58, were further investigated in rats and dogs. 1-(2, 6-Di-tert-butyl-4-trans- styrylphenoxy)-3-isopropylamino-2-propanol (4) possessed considerable lipid catabolic ...