Combination of the Topliss Approach with the Free-Wilson Analysis in the Study of Antimycobacterial Activityof 4-Alkylthiobenzanilides

J Kuneš, J Jáchym, P Jirásko, Ž Odlerová…

Index: Kunes, Jiri; Jachym, Jiri; Jirasko, Petr; Odlerova, Zelmira; Waisser, Karel Collection of Czechoslovak Chemical Communications, 1997 , vol. 62, # 9 p. 1503 - 1510

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Citation Number: 10

Abstract

Abstract On the basis of a preliminary study of the antimycobacterial activity of thiobenzanilides, a group of 4'-isopropyl-and 4'-butylthiobenzanilides have been synthesized and tested against Mycobacterium tuberculosis, Mycobacterium kansasii, Mycobacterium avium and Mycobacterium fortuitum. The effect of the substituents on minimum inhibitory concentrations was calculated by the Free-Wilson method. The ...