The synthesis of bisguanidinoalkanes and guanidinoalkanes, N-or N'-substituted with pyrimidines, as analogues of chlorhexidine

BC Elmes, G Holan, GT Wernert, DA Winkler

Index: Elmes, Bryan C.; Holan, George; Wernert, Gregory T.; Winkler, David A. Australian Journal of Chemistry, 1996 , vol. 49, # 5 p. 573 - 579

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Citation Number: 4

Abstract

Abstract A series of N, N???-alkanediylbis [N?-(5-halopyrimidin-2-yl) guanidine] salts has been synthesized along with N, N???-(trans-cyclohexane-1, 4-diyl) bis [N'-(5- chloropyrimidin-2-yl) guanidine], N, N???-(cis-cyclohexane-1, 4-diyl) bis [N?-(5- chloropyrimidin-2-yl) guanidine] dihydrochloride and N-(cis-4-amino-cyclohexan-1-yl)-N'-(5- chloropyrimidin-2-yl) guanidine dihydrochloride. Furthermore, a series of N-(alkan-1-yl)-N ...