Highly regioselective functionalization of 2, 3-dialkyl substituents on indoles

Y Naruse, Y Ito, S Inagaki

Index: Naruse, Yuji; Ito, Yoshitaka; Inagaki, Satoshi Journal of Organic Chemistry, 1991 , vol. 56, # 6 p. 2256 - 2258

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Citation Number: 26

Abstract

Direct functionalization of the side chains of heteroaromatic nuclei continues to be a significant challenge for the construction of complex alkaloids.'The a-metalation of alkyl substituents is one of the most attractive routes for this modifications2 Although the indole and pyrrole rings are widely found in bioactive compounds, little attention has been paid to the deprotonation of the alkyl side chains on these n-excessive heteroaromatics. During ...