Biological Mass Spectrometry

A re??examination of the synthesis and some properties of the in vitro metabolite, N??hydroxyphenmetrazine

RT Coutts, R Dawe, AH Beckett

Index: Coutts,R.T. et al. Biomedical Mass Spectrometry, 1975 , vol. 2, p. 137 - 141

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Citation Number: 2

Abstract

Abstract The reported synthesis of N-hydroxyphenmetrazine from phenmetrazine by the action of m-chloroperbenzoic acid could not be repeated. When the synthetic procedure was modified N-hydroxyphenmetrazine was obtained in low yield. The product had different properties from those claimed previously, but was identical to metabolically produced N- hydroxyphenmetrazine. It was characterized by means of thin-layer chromatography, ...