Enantioselective preparation and structural and conformational analysis of the chiral solvating agent α, α′-bis (trifluoromethyl)-1, 8-anthracenedimethanol

…, I Maestre, C Jaime, A Alvarez-Larena, JF Piniella…

Index: Perez-Trujillo, Miriam; Maestre, Itziar; Jaime, Carlos; Alvarez-Larena, Angel; Piniella, Juan Francesc; Virgili, Albert Tetrahedron Asymmetry, 2005 , vol. 16, # 18 p. 3084 - 3093

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Citation Number: 29

Abstract

The determination of enantiomeric composition by NMR using the addition of a chiral solvating agent (CSA) has been shown 1 to be a valid methodology. After the description of the highly useful 2 Pirkle alcohol, 3 several molecules have been used as CSAs: derivatives of binaphthol 4 or of natural compounds such as quinine 5 and others 6 that form hydrogen bonds or dipolar or π-stacking interactions to generate relatively stable supramolecular entities. ...