The Journal of antibiotics

Synthesis and biological activity of quaternary ammoniopropenyl cephalosporins having two vinyl groups.

JH Kang, SW Yu, SY Lee, KW Kim

Index: Kang, Jae-Hoon; Yu, Seung-Woo; Lee, Seung-Young; Kim, Kee-Won Journal of Antibiotics, 1998 , vol. 51, # 3 p. 378 - 380

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Citation Number: 1

Abstract

To a solution of allylcyanide (1; 4g, 59.62 mmol) in tert-butanol (6ml) and petroleum ether (27ml) was added bromine (9.5 g, 59.62 mmol) at 15, and then stirred at room temperature for 20 minutes. A solution of 21% sodium ethoxide (19.3 g, 59.62 mmol) was added dropwise to the mixture and the solid was filtered off. The filtrate was distilled under reduced pressure to give 4-bromo-2-butenenitrile (3) 8) as a liquid (4.6 g, 52.8%).