Synthesis and in Vivo Evaluation of [123I] Melanin-Targeted Agents

…, RJ Hicks, A Katsifis, I Greguric

Index: Pham, Tien Q.; Greguric, Ivan; Liu, Xiang; Berghofer, Paula; Ballantyne, Patrice; Chapman, Janette; Mattner, Filomena; Dikic, Branko; Jackson, Timothy; Loc'h, Christian; Katsifis, Andrew Journal of Medicinal Chemistry, 2007 , vol. 50, # 15 p. 3561 - 3572

Full Text: HTML

Citation Number: 2

Abstract

This study reports the synthesis,[123I] radiolabeling, and biological profile of a new series of iodinated compounds for potential translation to the corresponding [131I] radiolabeled compounds for radionuclide therapy of melanoma. Radiolabeling was achieved via standard electrophilic iododestannylation in 60–90% radiochemical yield. Preliminary SPECT imaging demonstrated high and distinct tumor uptake of all compounds, as well as ...