Synthesis and biological evaluation of phenyl substituted polyoxygenated xanthone derivatives as anti-hepatoma agents

M Dai, X Yuan, J Kang, ZJ Zhu, RC Yue, H Yuan…

Index: Dai, Ming; Yuan, Xing; Kang, Jian; Zhu, Zhi-Jun; Yue, Rong-Cai; Yuan, Hu; Chen, Bing-Yang; Zhang, Wei-Dong; Liu, Run-Hui; Sun, Qing-Yan European Journal of Medicinal Chemistry, 2013 , vol. 69, p. 159 - 166

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Citation Number: 4

Abstract

Abstract A series of novel derivatives of phenyl substituted tetramethoxy xanthone were synthesized and evaluated for their in vitro cytotoxicity against human hepatocellular carcinoma (HCC) and non-tumor hepatic cells. Among these derivatives, compound 6 was more potent than positive control 5-fluorouracil (5-Fu) on QGY-7703 and SMMC-7721 cells with IC 50 values of 6.27 μM, 7.50 μM and 15.56 μM, 14.55 μM, respectively. Furthermore, ...