New 3-and 4-hydroxyfuranones as anti-oxidants and anti-inflammatory agents

…, C Rubat, E Duroux, C Lartigue, M Madesclaire…

Index: Weber, Valerie; Rubat, Catherine; Duroux, Eliane; Lartigue, Claire; Madesclaire, Michel; Coudert, Pascal Bioorganic and Medicinal Chemistry, 2005 , vol. 13, # 14 p. 4552 - 4564

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Citation Number: 50

Abstract

Two series of new furanones substituted by methylsulfonylphenyl or methylsulfamidophenyl moieties were found to protect against oxidation damage by inhibiting or quenching free radicals and reactive oxygen species in in vitro experiments. The effect on lipid peroxidation was also examined. In addition, we investigated the activity of products in two models of inflammation: phorbol ester-induced ear edema in mice and carrageenan-induced paw ...

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New 3-and 4-hydroxyfuranones as anti-oxidants and anti-inflammatory agents

Abstract

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