An acid-catalyzed macrolactonization protocol
BM Trost, JD Chisholm
Index: Trost, Barry M; Chisholm, John D Organic letters, 2002 , vol. 4, # 21 p. 3743 - 3745
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Citation Number: 62
Abstract
An efficient macrolactonization protocol devoid of any base was developed derived from the use of vinyl esters in transesterification. Subjecting a hydroxy acid and ethoxyacetylene to 2 mol%[RuCl2 (p-cymene)] 2 in toluene followed by addition of camphorsulfonic acid or inverse addition provided macrolactones in good yields.
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