Synthesis of 4-(1-oxo-isoindoline) and 4-(5, 6-dimethoxy-1-oxo-isoindoline)-substituted phenoxypropanolamines and their β 1-, β 2-adrenergic receptor binding …

…, B Singh, MS Coumar, G Bruni, P Massarelli

Index: Jindal, Dharam P.; Singh, Babita; Coumar, Mohane S.; Bruni, Giancarlo; Massarelli, Paola Bioorganic Chemistry, 2005 , vol. 33, # 4 p. 310 - 324

Full Text: HTML

Citation Number: 7

Abstract

Phenoxypropanolamines with 1-oxo-isoindoline (12–16) and 5, 6-dimethoxy-1-oxo- isoindoline groups (17–20) at the para position were synthesized. β1, β2-Adrenergic receptor binding affinities for the synthesized compounds were tested and compared with propranolol and atenolol. It was found that the incorporation of para-amidic functionality within the 1-oxo-isoindoline ring and 5, 6-dimethoxy-1-oxo-isoindoline ring system led to a ...