Tetrahedron Letters

Efficient synthesis of unsymmetric diarylalkynes from decarboxylative coupling in a continuous flow reaction system

HJ Lee, K Park, G Bae, J Choe, KH Song, S Lee

Index: Lee, Hee Joon; Park, Kyungho; Bae, Goun; Choe, Jaehoon; Song, Kwang Ho; Lee, Sunwoo Tetrahedron Letters, 2011 , vol. 52, # 39 p. 5064 - 5067

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Citation Number: 16

Abstract

Unsymmetric diaryl alkynes were synthesized from the palladium-catalyzed decarboxylative coupling of aryl halides and propiolic acid using a continuous flow reaction system. This flow chemistry system continuously gave the desired products in moderate to good yields, and produced less byproduct than was formed in the batch reaction.

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