Unexpected formation of pyridodiindole derivatives with cytotoxic activity via double nenitzescu reaction

…, R Troschütz, R Grünert, P Bednarski

Index: Willemann, Christine; Waibel, Reiner; Gruenert, Renate; Bednarski, Patrick; Troschuetz, Reinhard Journal of Heterocyclic Chemistry, 2008 , vol. 45, # 5 p. 1517 - 1519

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Citation Number: 4

Abstract

Dotzauer et al. synthesized 2, 4-diamino-9H-pyrimido [4, 5-b] indol-6-ole (1) and N- substituted derivatives as a prototype of a series of ellipticine analogues by an extension of the Nenitzescu reaction using 1, 4-benzoquinone (4) and pyrimidine-2, 4, 6-triamines. These indole derivatives showed interesting antitumor activity [1-3]. Related to these compounds, we planned pyridine-2, 4, 6-triamine (5) to react as a new type of enamine component with ...