A new sequential defluorination route to α-fluoro-α, β-unsaturated ketones from trifluoromethyl ketones

H Hata, T Kobayashi, H Amii, K Uneyama, JT Welch

Index: Hata, Hiroshi; Kobayashi, Takeshi; Amii, Hideki; Uneyama, Kenji; Welch, John T. Tetrahedron Letters, 2002 , vol. 43, # 35 p. 6099 - 6102

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Citation Number: 50

Abstract

α-Fluoro-α, β-unsaturated ketones were prepared from trifluoromethyl ketones via a sequence involving Mg metal promoted successive double defluorination. Trifluoromethyl ketones were transformed to β, β-difluoroenol silyl ethers which were then coupled with ...