Model studies support pyrrolylation of the topaquinone cofactor to explain inactivation of bovine plasma amine oxidase by 3-pyrrolines. Unusual processing of a …

Y Lee, H Huang, LM Sayre

Index: Lee, Younghee; Huang, He; Sayre, Lawrence M. Journal of the American Chemical Society, 1996 , vol. 118, # 30 p. 7241 - 7242

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Citation Number: 32

Abstract

Since the report in 1990 that the active carbonyl cofactor used by plasma and other copper amine oxidases is the quinone form (topaquinone, TPQ) of an active site 2, 4, 5- trihydroxyphenylalanine residue, 1 there has been renewed interest in mechanistic and directed model studies. 2-7 A pyridoxal-like transamination mechanism appears to be in force for the enzyme (Scheme 1, path A), since anaerobic single turnover results in ...