Duloxetine (Cymbalta™), a dual inhibitor of serotonin and norepinephrine reuptake

…, JH Krushinski, S Mitchell, DW Robertson…

Index: Bymaster; Beedle; Findlay; Gallagher; Krushinski; Mitchell; Robertson; Thompson; Wallace; Wong Bioorganic and medicinal chemistry letters, 2003 , vol. 13, # 24 p. 4477 - 4480

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Citation Number: 100

Abstract

A series of naphthalenyloxy-arylpropylamines have been prepared and are demonstrated to be inhibitors of both serotonin and norepinephrine reuptake. One member of this series, duloxetine (Cymbalta™) has proven to be effective in clinical trials for the treatment of depression.

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