Selective palladium-catalyzed aminations on 2-chloro-3-iodo-and 2-chloro-5-iodopyridine

BUW Maes, KTJ Loones, THM Jonckers, GLF Lemière…

Index: Maes, Bert U. W.; Loones, Kristof T. J.; Jonckers, Tim H. M.; Lemiere, Guy L. F.; Dommisse, Roger A.; Haemers, Achiel Synlett, 2002 , # 12 p. 1995 - 1998

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Citation Number: 13

Abstract

Abstract Regioselective palladium-catalyzed aminations with anilines on 2-chloro-3-iodo- and 2-chloro-5-iodopyridine have been performed with excellent yields and good selectivity. The use of a large excess of Cs 2 CO 3 in combination with Pd-BINAP catalyst was essential to obtain sufficiently fast reactions. The mild conditions permit the presence of base sensitive functional groups. Moreover, the catalytic system developed also allows the arylamination ...