A simple and efficient approach for the synthesis of fluorinated and nonfluorinated octaethylporphyrin-based benzochlorins with variable lipophilicity, their in …

…, ZD Grossman, A Oseroff, TJ Dougherty…

Index: Li; Graham; Potter; Grossman; Oseroff; Dougherty; Pandey Journal of Organic Chemistry, 2001 , vol. 66, # 4 p. 1316 - 1325

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Citation Number: 20

Abstract

Starting from commercially available Ni (II) octaethylporphyrin (OEP), an efficient approach for the preparation of a series of fluorinated and nonfluorinated benzochlorins with variable lipophicity has been developed. Their spectroscopic properties, preliminary in vitro photosensitizing efficacy, and tumor selectivity were determined. Our methodology provides a facile approach for the preparation of the free-base and the related Zn (II) benzochlorins ...