Maleimidoethyl 3-(tri-n-butylstannyl) hippurate: A useful radioiodination reagent for protein radiopharmaceuticals to enhance target selective radioactivity localization

…, K Wakisaka, Y Ohmomo, T Uezono…

Index: Arano, Yasushi; Wakisaka, Kouji; Ohmomo, Yoshiro; Uezono, Takashi; Mukai, Takahiro; et al. Journal of Medicinal Chemistry, 1994 , vol. 37, # 16 p. 2609 - 2618

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Citation Number: 41

Abstract

In pursuit of radiolabeled monoclonal antibodies (mAbs) with rapid urinary excretion of radioactivity from nontarget tissues, radioiodinated mAbs releasing a m-iodohippuric acid from the mAbs in nontarget tissues were designed. A novel reagent, maleimidoethyl 3-(tri- nbutylstanny1) hippurate (MIH), was synthesized by reacting N-(hydroxyethy1) maleimide with N-Boc-glycine before coupling with N-succinimidyl3-(tri-n-butylstannyl) benzoate ( ...