Mild and facile procedure for clay-catalyzed acetonide protection and deprotection of N (Boc)-amino alcohols and protection of 1, 2-diols

…, SS Bhor, AS Gajare, VH Deshpande, RD Wakharkar

Index: Shaikh, Nadim S.; Bhor, Santosh S.; Gajare, Anil S.; Deshpande, Vishnu H.; Wakharkar, Radhika D. Tetrahedron Letters, 2004 , vol. 45, # 28 p. 5395 - 5398

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Citation Number: 18

Abstract

The application of clay as a catalyst for acetonide protection of N (Boc)-amino alcohols and 1, 2-diols to obtain good to excellent yields of the acetonide derivatives is described. Acetonide deprotection to obtain the parent amino alcohol was carried out using a similar catalyst in the presence of methanol as solvent. The reaction takes place at room temperature within 2h to give the parent amino alcohol in quantitative yield keeping the N ...