Synthesis of N, N??Disubstituted 1??Cyanocyclopropanecarboxamides

K Yamagata, F Okabe, Y Tagawa

Index: Yamagata, Kenji; Okabe, Fumi; Tagawa, Yoshinobu European Journal of Organic Chemistry, 2003 , # 13 p. 2383 - 2387

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Abstract

Abstract 2-(Disubstituted amino)-4, 5-dihydro-3-furancarbonitriles 1a− i reacted with acetyl chloride to yield the corresponding ring-opening products 2a− i. The cyclization of compounds 2a− f with bases gave the corresponding N, N-disubstituted 1- cyanocyclopropanecarboxamides 3a− c and (E)-1-cyano-2- phenylcyclopropanecarboxamides 3d− f. The same compounds 3d− f were also obtained ...