European journal of medicinal chemistry

Synthesis, physicochemical properties and antimicrobial activity of some new benzimidazole derivatives

KF Ansari, C Lal

Index: Ansari; Lal European Journal of Medicinal Chemistry, 2009 , vol. 44, # 10 p. 4028 - 4033

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Citation Number: 166

Abstract

Some derivatives of benzimidazole were synthesized by nucleophilic substitution of 2- substituted-1H-benzimidazole. The resulting ethyl (2-substituted-1H-benzimidazol-1-yl) acetate on treatment with hydrazine hydrate yielded 2-(2-substituted-1H-benzimidazol-1-yl) acetohydrazide, which on further reaction with one equivalent of different aliphatic or aromatic carboxylic acids in the presence of phosphoryl chloride afforded the ...

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