Copper-Catalyzed N-Arylation of Sulfonimidamides

S Azzaro, M Desage-El Murr, L Fensterbank, E Lacôte…

Index: Azzaro, Stephane; Murr, Marine Desage-El; Fensterbank, Louis; Lacote, Emmanuel; Malacria, Max Synlett, 2011 , # 6 p. 849 - 851

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Citation Number: 13

Abstract

An efficient copper-catalyzed method for introducing aryl substituents on the amino end of sulfonimidamides has been developed. Microwave irradiation allows for short reaction times and good yields, and a variety of aromatics can be coupled. ... Sulfonimidamides are chiral analogues of sulfonamides with a stereogenic sulfur atom. [¹] These compounds have been studied for potential biological applications as analogues of the aspartic acid transition state in metalloproteases, [²a] ...